Human Kidney vs Dialyzers

Human Kidney VS Dialyzers

High efficiency dialyzers have a urea clearance (K) of >200ml/min (as long as blood flow and dialysate flow are not limiting) but this decreases significantly with solutes of middle and high molecular weights such as β2 microglobulin (11,800 Da).

Dialyzers that are high flux (and typically also high efficiency - high Kuf and KoA) have high small solute (urea) clearance and high middle molecule clearance.

Normal kidneys have a urea clearance (K) of around 125ml/min stable across various molecular weights up to 50,000-60,000 daltons. Therefore human kidneys are high flux!